 |
Indication & Dosage |
| |
| |
| Oral |
| AS A 2ND LINE DRUG IN TUBERCULOSIS |
| Adult:
15-20 mg/kg daily as a single dose. Max dose: 1 g daily. |
| |
| Oral |
| AS A 2ND LINE DRUG IN TUBERCULOSIS |
| Child:
10-20 mg/kg daily as a single dose. Max dose: 750 mg daily. |
|
| |
|
| Precautions |
Difficulty in managing DM. Monitor blood glucose, thyroid and visual function. Perform LFT before and during treatment with protionamide. Caution in patients with psychiatric illness or depression. Pregnancy and lactation. |
| |
|
| Adverse Drug Reactions |
Anorexia, excessive salivation, metallic taste, nausea, vomiting, abdominal pain, diarrhoea. Peripheral and/or optic neuritis, psychiatric disturbances e.g. depression, anxiety, psychosis, postural hypotension. Jaundice, hepatitis. Thrombocytopenia, skin rashes, stomatitis, gynaecomastia. |
| |
|
| Interactions |
Increased neurotoxic effects with cycloserine. |
| |
|
|
|
