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Indication & Dosage |
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| |
| Oral |
| ATRIAL AND VENTRICULAR PREMATURE CONTRACTIONS |
| Adult:
As sulfate: 200-300 mg 3-4 times daily. |
| |
| Oral |
| UNCOMPLICATED PLASMODIUM FALCIPARUM MALARIA |
| Adult:
|
| |
| Oral |
| UNCOMPLICATED PLASMODIUM FALCIPARUM MALARIA |
| Child:
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| Oral |
| PAROXYSMAL SUPRAVENTRICULAR TACHYCARDIA |
| Adult:
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| Oral |
| CONVERSION OF ATRIAL FIBRILLATION |
| Adult:
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| Intravenous |
| CARDIAC ARRHYTHMIAS |
| Adult:
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| Intravenous |
| MALARIA |
| Adult:
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| Intravenous |
| MALARIA |
| Child:
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| Administration |
Should be taken with food. (Best taken at meal times.) |
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| Precautions |
Test dose is recommended. Atrial flutter; widening QRS complex; incomplete AV block; uncompensated heart failure, myasthenia gravis, acute infections, fever, digitalised patients; hypokalaemia; acute MI; obstructive GI tract changes; renal or hepatic impairment; elderly. Prolonged QT interval, history of torsade de pointes, myocarditis, severe myocardial damage. Rapid infusion may result in hypotension and vascular collapse. Pregnancy and lactation. |
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Potentially Life-threatening
Adverse Drug Reactions |
Muscle weakness, nausea, vomiting, diarrhoea; cinchonism symptoms including impaired hearing, headache, blurred vision, dizziness and vomiting; urticaria and skin reactions. |
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| Adverse Drug Reactions |
Asystole, syncope, ventricular fibrillation. Thrombocytopenia, exfoliative dermatitis, granulomatous hepatitis (hypersensitivity); CHF; heart block, ventricular arrhythmias, tachycardia, seizure, coma. |
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| Interactions |
Increases plasma digitalis concentration. May enhance effects of antihypertensives, vasodilators, myocardiac depressants, oral anticoagulants and non-depolarizing muscle relaxants. Reduced clearance when used with drugs that alkalinise the urine eg. thiazides. Increased plasma levels when used with cimetidine or amiodarone. Increased metabolism when used with enzyme inducers eg. phenobarbital, phenytoin and rifampicin. Decreased metabolism when used with verapamil. Increased serum levels of procainamide and haloperidol. |
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