CHF or active malignancy; history of oestrogen-induced hypertriglyceridaemia; renal insufficiency.
Potentially Life-threatening
Adverse Drug Reactions
Hot flushes, leg cramps, sweating, sleep disorders, peripheral oedema, vag bleeding; flu-like symptoms, rashes, GI disturbances, hypertension, headache, sinusitis, arthralgia.
Adverse Drug Reactions
Endometrial carcinoma and thromboembolic events.
Interactions
Cholestyramine reduces the absorption of raloxifene. Raloxifene with warfarin may reduce the prothrombin response and time. Caution when used in hghly protein-bound drugs such as diazepam, lidocaine and diazoxide.