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Indication & Dosage |
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| Oral |
| TREATMENT OF DEPRESSION |
Adult:
4 mg bid, may increase to 10 mg after 3-4 wk if necessary. Max dose: 12 mg daily.
Elderly: Not recommended. |
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| Administration |
May be taken with or without food. |
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| Precautions |
Renal and hepatic impairment, benign prostatic hyperplasia, cardiac disorders, epilepsy, bipolar disorders, urinary retention, glaucoma. May impair ability to perform tasks requiring mental alertness, driving or operating machinery. Monitor for signs of clinical worsening eg. suicidal tendency especially during the initial phase of the treatment. |
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Potentially Life-threatening
Adverse Drug Reactions |
Insomnia, dizziness, increased sweating, impotence, dry mouth, constipation, urinary hesitancy, dry mouth, postural hypotension, dysuria, paraesthesia, hyponatraemia, tachycardia. |
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| Adverse Drug Reactions |
Tachycardia. |
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| Interactions |
Risk of hypertensive crisis when used with MAOIs. Avoid concomitant admin with antiarrhythmics, antipsychotics, ciclosporin, imidazole and triazole antifungals, TCAs. Concurrent use with CYP3A4 inhibitors may increase plasma levels of reboxetine. Concurrent use with ergot derivatives may increase BP. |
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