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testing

 
   
EMPETUS  RITOMAX  RITOMUNE  RITOVIR 
 



Indication & Dosage
 
 
Oral
HIV INFECTION COMBINED WITH OTHER ANTIRETROVIRALS
Adult: Initially, 300 mg bid for 1 day. May increase dose gradually by 100 mg bid over a period of 14 days to 600 mg bid.
 
Oral
HIV INFECTION COMBINED WITH OTHER ANTIRETROVIRALS
Child: >2 yr: 250 mg/m2 bid. Increase dose by 50 mg/m2 bid at 2-3 day intervals up to 400 mg/m2 bid. Max dose: 600 mg bid.
 
Oral
AS A PHARMACOKINETIC ENHANCER
Adult: To enhance the efficacy of other protease inhibitors: 100-200 mg once or twice daily.
   
Administration Should be taken with food.
   
Precautions Pregnancy; child; hepatic impairment; DM; haemophilia; pancreatitis. Monitor glucose, lipid, uric acid and blood counts. Ensure adequate hydration to reduce risk of nephrolithiasis. Discontinue treatment if patient develops haemolytic anaemia.
   
Potentially Life-threatening 
Adverse Drug Reactions
Syncope, orthostatic hypotension; dry mouth, mouth ulcers, throat irritation, cough; dyspepsia, nausea, vomiting, diarrhoea, taste disturbance, seizures, anxiety, sweating, fever, asthenia, fatigue, headache, dizziness, paraesthesia, myalgia, skin rashes, pruritus, renal insufficiency, anaemia, raised WBC, raised prothrombin time, lipodystrophy, pancreatitis, electrolyte imbalance.
   
Adverse Drug Reactions Hypersensitivity, anaphylaxis and Stevens-Johnson syndrome.
   
Interactions Decreased plasma conc with phenobarbital, carbamazepine, dexamethasone, phenytoin, rifabutin and rifampicn. Increased plasma conc of certain drugs highly metabolized by CYP3A. May increase serum levels of sildenafil.
   
   
 

 

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