Indication & Dosage |
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Oral |
ACUTE MIGRAINE ATTACKS |
Adult:
Initially, 10 mg. If ineffective, 2nd dose should not be taken for the same attack. If symptoms recur after initial response, a further dose of 10 mg may be given. Doses should be separated by at least 2 hr. Max: 20 mg/24 hr. If patient is also taking propanolol, initiate with 5 mg. |
Max Dosage: 10 mg/24 hr. Ensure that the 2 drugs are separated |
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Administration |
May be taken with or without food. Orally disintegrating tab: May be taken with or without food. (Place on the tongue & allow to dissolve; it can then be swallowed w/ the saliva.) |
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Precautions |
Elderly; mild to moderate hepatic or renal impairment; coronary artery disease; pregnancy, lactation. May cause drowsiness. History of seizures. Ensure an interval of at least 24 hr after stopping an ergotamine compound and starting a serotonin (5-HT1) agonist. |
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Potentially Life-threatening
Adverse Drug Reactions |
Increased BP, chest pain, palpitation; skin flushing; dyspnoea; nausea, abdominal pain, dry mouth; dizziness, drowsiness, fatigue. |
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Adverse Drug Reactions |
Toxic epidermal necrolysis. |
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Interactions |
ncreased serum concentrations with propranolol. Increased risk of vasospastic reactions when used with ergotamine and methysergide. Concurrent use with SSRIs may increase risk of serotonin syndrome. |
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