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Indication & Dosage |
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| Oral |
| TREATMENT OF ZOLLINGER-ELLISON SYNDROME |
| Adult:
75 mg bid. |
| |
| Oral |
| PREMEDICATION IN ANAESTHESIA |
| Adult:
75 mg in the evening on the day before surgery and repeated 2 hr before induction of anaesthesia. Alternatively, 150 mg once on the night before surgery. |
| |
| Oral |
| GASTRITIS |
| Adult:
75 mg once daily in the evening. |
| |
| Oral |
| TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE WITH OR WITHOUT OESOPHAGITIS INCLUDING EROSIONS AND ULCERATIONS |
| Adult:
75 mg bid or 150 mg at bedtime for 6-8 wk |
| |
| Oral |
| PEPTIC ULCER |
| Adult:
150 mg at bedtime or 75 mg bid daily for 4-6 wk. Maintenance: 75 mg at bedtime. |
| |
| Intravenous |
| TREATMENT OF UPPER GI TRACT HAEMORRHAGE |
| Adult:
75 mg bid via slow inj or infusion. |
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| Precautions |
Renal and hepatic impairment, pregnancy. May mask the symptoms of gastric malignancy. |
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| Adverse Drug Reactions |
Occasional headache, GI disturbances, gynaecomastia, alopoecia, blood dyscrasias, pancreatitis, sleep disturbances, restlessness, rarely dizziness. Hypersensitivity reactions e.g. rash and itching reported occasionally. Changes in pulse rate and transient impairment of sexual drive. Possible increase in liver enzyme activity. May reduce leucocytes and/or thrombocytes. |
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| Interactions |
May affect serum levels of protease inhibitors. |
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