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Indication & Dosage |
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| Oral |
| TREATMENT OF EARLY PARKINSONISM |
Adult:
As conventional preparations: 10 mg daily either as a single dose in the morning or in 2 divided doses of 5 mg at breakfast and lunchtime. As oral lyophilisate tablets: Initially, 1.25 mg daily.
Elderly: Initially, 2.5 mg daily. |
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| Transdermal |
| TREATMENT OF MAJOR DEPRESSIVE DISORDER |
| Adult:
Initially, 6 mg/24 hr, dose may be increased in steps of 3 mg/24 hr at intervals of not <2 wk. Patients on doses ranging from 9-12 mg/24 hr should avoid tyramine-rich foods during and for 2 wk after discontinuing the treatment. Patches should be changed every 24 hr and the new patch is applied to a different site. Max: 12 mg/24 hr. |
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| Administration |
Should be taken with food. |
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| Precautions |
History of peptic ulcer, uncontrolled hypertension, arrhythmias, angina, psychosis. Severe liver or kidney dysfunction. |
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| Adverse Drug Reactions |
Hallucinations, dizziness, confusion, anxiety, dreams, palpitations, syncope, irritability, restlessness, nausea, dry mouth, sexual dysfunction, hypotension, arrhythmia, angina, tachycardia. Orthostatic hypotension, chest pain, insomnia, abnormal dreams. Transient elevations in liver enzymes. |
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| Interactions |
Risk of muscular rigidity, severe agitation and elevated temperature when used with meperidine. Increased risk of toxicity when used with TCAs or SSRIs. Risk of orthostatic hypotension when used with bupropion. Amantadine may increase BP when used together. Risk of hypertensive effect when used with dopamine. Concurrent use with dextromethorphan increases the risk of adverse effects. |
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