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Indication & Dosage |
| |
| |
| Oral |
| HEREDITARY ANGIOEDEMA |
| Child:
<6 yr: 1 mg daily; 6-12 yr: Up to 2 mg daily. |
| |
| Oral |
| HEREDITARY ANGIOEDEMA |
| Adult:
Initially, 2.5-10 mg daily, reduced according to response. Maintenance: 2 mg daily or on alternate days or 2.5 mg 3 times wkly. |
| |
| Oral |
| VASCULAR MANIFESTATIONS OF BEHCET'S SYNDROME |
| Adult:
10 mg daily |
| |
| Intramuscular |
| ANAEMIAS |
| Adult:
50 mg every 2-3 wk. |
| |
| Intramuscular |
| OSTEOPOROSIS IN WOMEN AND MEN |
| Adult:
50 mg every 2-3 wk. |
| |
| Intramuscular |
| CATABOLIC DISORDERS |
| Adult:
50 mg every 2-3 wk |
| |
| Intramuscular |
| BREAST CANCER IN POSTMENOPAUSAL WOMEN |
| Adult:
50 mg every 2-3 wk |
|
| |
|
| Precautions |
Patients with cardiac, renal or hepatic disease, epilepsy or DM. Children, elderly. Monitor liver function, haematocrit and haemoglobin concentrations. Not recommended for treatment of hereditary angioedema in premenopausal women. |
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|
Potentially Life-threatening
Adverse Drug Reactions |
Peliosis hepatis, premature epiphyseal closure, cholestatic jaundice, virilism, impotence, priapism, testicular atrophy, gynaecomastia, prostatic hyperplasia, decreased libido, hirsutism, menstrual irregularities; oedema, acne. |
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|
| Adverse Drug Reactions |
Hepatic necrosis, hepatocellular carcinoma. |
| |
|
| Interactions |
Enhances activity of insulin, sulfonylureas, levothyroxine and anticoagulants e.g. warfarin. May cause resistance to the effects of neuromuscular blockers. |
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