| |
| |
| Intramuscular |
| TUBERCULOSIS |
| Adult:
15 mg/kg daily; max: 1 g daily. For intermittent therapy: 25-30 mg/kg/day 2-3 times/wk; |
| Max Dosage: 1.5 g/dose. |
| |
| Intramuscular |
| TUBERCULOSIS |
| Child:
20–40 mg/kg (max: 1 g) daily or 25–30 mg/kg (max: 1.5 g) 2–3 times wkly.
Elderly: ≥60 kg: Dosage reduction is required. |
| |
| Intramuscular |
| MYCOBACTERIUM AVIUM COMPLEX INFECTIONS |
| Adult:
As adjunct therapy (with macrolide, rifamycin and ethambutol): 15 mg/kg 3 times wkly for first 2-3 mth for severe disease. Longer duration may be needed in patients with extensive disease or when other agents are poorly tolerated.
Elderly: ≥60 yr: Dosage reduction is required. |
| |
| Intramuscular |
| BACTERIAL ENDOCARDITIS |
| Adult:
To be used concurrently with penicillin. Streptococcal endocarditis: 1 g bid for the first wk, 500 mg bid for the second wk. Enterococcal endocarditis (in combination with penicillin): 1 g bid for 2 wk and 500 mg bid for an additional 4 wk; ototoxicity may necessitate termination of streptomycin before the completion of the 6-wk therapy. |
| |
| Intramuscular |
| BACTERIAL ENDOCARDITIS |
| Child:
To be used concurrently with penicillin. Enterococcal endocarditis: 20–30 mg/kg daily given in 2 divided doses. Recommended treatment duration: 4-6 wk for patients native valve endocarditis and at least 6 wk for patients with prosthetic valve or other prosthetic cardiac material. |
| |
| Intramuscular |
| BRUCELLOSIS |
| Adult:
1 g/day for 14-21 days. To be used with oral doxycycline at 100 mg bid for 6 wk. |
| |
| Intramuscular |
| BRUCELLOSIS |
| Child:
≥7 yr: 1 g/day (for patients ≤50 kg: 15 mg/kg daily) for 14 days . To be used with oral doxycycline at 100 mg bid for 6 wk. |
| |
| Intramuscular |
| PLAGUE |
| Adult:
1 g or 15 mg/kg (up to 1 g) bid. Recommended treatment duration: At least 10 days. |
| |
| Intramuscular |
| PLAGUE |
| Child:
30 mg/kg daily (max: 2 g daily) given in 2 or 3 divided doses. Recommended treatment duration: At least 10 days. |
| |
| Intramuscular |
| TULARAEMIA |
| Adult:
1–2 g daily given in divided doses for 7–14 days and until the patient is afebrile for 5–7 days |
| |
| Intramuscular |
| TULARAEMIA |
| Child:
15 mg/kg bid (max: 2 g daily) for at least 10–14 days |
