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Indication & Dosage |
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| Oral |
| CHRONIC IDIOPATHIC CONSTIPATION |
| Adult:
6 mg taken bid for 4-6 wk continued for another 4-6 wk in responsive patients. |
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| Oral |
| IRRITABLE BOWEL SYNDROME WITH CONSTIPATION IN WOMEN |
| Adult:
6 mg taken bid for 4-6 wk continued for another 4-6 wk in responsive patients. |
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| Administration |
Should be taken on an empty stomach (i.e. At least one hour before food or four hours after food). (Take on an empty stomach before meals.) |
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| Precautions |
Discontinue immediately if rectal bleeding, bloody diarrhoea, new or sudden worsening of abdominal pain occurs. Mild hepatic impairment; child <18 yr; pregnancy. |
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Potentially Life-threatening
Adverse Drug Reactions |
Diarrhoea, abdominal pain, nausea, flatulence, headache, dizziness, migraine, leg or back pain, arthropathy, insomnia, hypotension, arrhythmia, ischaemic colitis. |
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| Adverse Drug Reactions |
MI, stroke. |
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