Indication & Dosage |
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| Topical/Cutaneous |
| DERMATOPHYTE INFECTIONS |
| Adult:
Apply a 1% cream/solution once or bid. 1-2 wk to treat tinea corporis and tinea cruris; 1-wk course is for tinea pedis; 2-wk course in cutaneous candidiasis and pityriasis versicolor |
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| Oral |
| DERMATOPHYTE INFECTIONS |
| Child:
10-20 kg: 62.5 mg; 20-40 kg: 125 mg; >40 kg: 250 mg. Doses to be taken once daily. Treatment is usually given for 2 wk for tinea capitis; 2-4 wk for tinea cruris; 4 wk for tinea corporis; 6 wk in tinea pedis; 6-12 wk for nail infections. |
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| Oral |
| DERMATOPHYTE INFECTIONS |
| Adult:
250 mg once daily for 2-4 wk in tinea cruris, 6 wk for tinea pedis, 4 wk for tinea corporis and 6-12 wk for nail infections. |
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| Administration |
May be taken with or without food. |
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| Precautions |
Preexisting liver or renal impairment, pregnancy. Perform liver function tests prior to oral therapy. |
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Potentially Life-threatening
Adverse Drug Reactions |
Anorexia, nausea, abdominal pain, taste disturbances, diarrhoea, rash, urticaria. |
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| Adverse Drug Reactions |
Liver failure, Stevens-Johnson syndrome, neutropaenia. |
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| Interactions |
Possible increase in levels in drugs metabolised by CYP450 2D6. Decreased terbinafine concentration with rifampicin; increased terbinafine concentration with cimetidine. |
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