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Indication & Dosage |
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Oral |
CHOREA, BALLISM AND OTHER HYPERKINETIC MOVEMENT DISORDERS |
Adult:
Initially 12.5 mg bid, increased gradually to 12.5-25 mg tid. Max: 200mg daily. If no improvement at max dose for 7 days, drug unlikely to be of benefit. Elderly: Initially 12.5 mg daily, increased gradually. |
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Oral |
MODERATE TO SEVERE TARDIVE DYSKINESIA |
Adult:
Initially 12.5 mg daily increased gradually according to response. |
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Precautions |
May exacerbate symptoms of parkinsonism. Caution to be exercised when driving or performing skilled tasks. Pregnancy. |
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Potentially Life-threatening
Adverse Drug Reactions |
Drowsiness, extrapyramidal symptoms, parkinsonism, depression, orthostatic hypotension, GI disturbances. |
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Adverse Drug Reactions |
Neuroleptic malignant syndrome (NMS). |
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Interactions |
Tetrabenazine should not be given with or within 14 days of discontinuation of MAOI therapy. Blocks action of reserpine. Decreases effects of levodopa and worsen parkinsonism. Increased risk of extrapyramidal side effects when given with amantadine, metoclopramide, antipsychotics. |
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