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Indication & Dosage |
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| Parenteral |
| SUSCEPTIBLE INFECTIONS |
| Adult:
IM/IV infusion in 50-100 ml of 0.9% sodium chloride or 5% glucose over 20-60 min: 3-5 mg/kg or up to 8-10 mg/kg in daily in 3 or 4 divided doses for 7-10 days. |
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| Parenteral |
| SUSCEPTIBLE INFECTIONS |
| Child:
IM/IV infusion over 20-60 min: 6-7.5 mg/kg daily in 3-4 divided doses; premature and full-term neonates: 2 mg/kg bid. Treatment is given for 7-10 days. |
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| Parenteral |
| PSEUDOMONAL INFECTIONS |
| Adult:
IM/IV infusion in 50-100 ml of 0.9% sodium chloride or 5% glucose over 20-60 min: 3-5 mg/kg or up to 8-10 mg/kg in daily in 3 or 4 divided doses for 7-10 days. |
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| Parenteral |
| PSEUDOMONAL INFECTIONS |
| Child:
IM/IV infusion in 50-100 ml of 0.9% sodium chloride or 5% glucose over 20-60 min: 3-5 mg/kg or up to 8-10 mg/kg in daily in 3 or 4 divided doses for 7-10 days. |
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| Parenteral |
| MILD TO MODERATE URINARY TRACT INFECTIONS |
| Adult:
IM/IV infusion in 50-100 ml of 0.9% sodium chloride or 5% glucose over 20-60 min: 3-5 mg/kg or up to 8-10 mg/kg in daily in 3 or 4 divided doses for 7-10 days. |
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| Ophthalmic |
| EYE INFECTIONS |
| Adult:
IM/IV infusion in 50-100 ml of 0.9% sodium chloride or 5% glucose over 20-60 min: 3-5 mg/kg or up to 8-10 mg/kg in daily in 3 or 4 divided doses for 7-10 days. |
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| Inhalation |
| PSEUDOMONAS AERUGINOSA INFECTIONS IN PATIENTS WITH CYSTIC FIBROSIS |
| Adult:
IM/IV infusion in 50-100 ml of 0.9% sodium chloride or 5% glucose over 20-60 min: 3-5 mg/kg or up to 8-10 mg/kg in daily in 3 or 4 divided doses for 7-10 days. |
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| Precautions |
Preexisting renal and auditory or vestibular impairment; dehydration; neuromuscular blockade, muscular disorders (e.g. myasthenia gravis, parkinsonism); neonates; elderly; lactation. Avoid peak plasma concentrations > 10 mcg/ml or trough concentrations >2 mcg/ml when used parenterally. |
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Potentially Life-threatening
Adverse Drug Reactions |
Nausea, vomiting, dizziness or vertigo, acute renal failure, interstitial nephritis, acute tubular necrosis, electrolyte imbalances, purpura, encephalopathy, convulsions, mental depression, hallucinations, ototoxicity, blood dyscrasias, increased LFT and bilirubin concentrations. Topical: Ocular toxicity and hypersensitivity reactions (e.g. itching and oedema of the eyelid), conjunctival erythema, punctate keratitis and tearing. |
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| Adverse Drug Reactions |
Neuromuscular blockade, respiratory paralysis, anaphylaxis. |
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| Interactions |
Increased nephrotoxicity or ototoxicity with etacrynic acid, furosemide, other aminoglycosides, cefalotin, cisplatin, vancomycin, piperacillin, ciclosporin, amphotericin B. Decrease serum tobramycin levels with miconazole. |
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