 |
Indication & Dosage |
| |
| |
| Oral |
| OSTEOARTHRITIS |
| Adult:
10 mg once daily. |
| |
| Oral |
| RHEUMATOID ARTHRITIS |
| Adult:
|
| |
| Oral |
| DYSMENORRHEA |
| Adult:
|
|
| |
|
| Administration |
May be taken with or without food. |
| |
|
| Precautions |
Mild to moderate hepatic impairment; history of ulcer disease or GI bleeding; dehydration, hypertension, history of heart failure, left ventricular dysfunction, pre-existing oedema. Monitor Hb or haematocrit values for signs and symptoms of anaemia. |
| |
|
Potentially Life-threatening
Adverse Drug Reactions |
Hypertension, back pain, myalgia, peripheral oedema, influenza-like symptoms, dizziness, headache, abdominal fullness, abdominal pain, diarrhoea, dyspepsia, flatulence, nausea, myalgia, sinusitis. |
| |
|
| Adverse Drug Reactions |
Toxic epidermal necrolysis, exfoliative dermatitis. |
| |
|
| Interactions |
Concomitant admin of aspirin may result in an increased risk of GI ulceration and complications. It decreases the antihypertensive effect of antihypertensives e.g. ACE inhibitors. It increases plasma conc of dextromethorphan. It significantly decreases lithium serum clearance and renal clearance. |
| |
|
|
|
