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Indication & Dosage
 
 
Oral
STAPHYLOCOCCAL ENTEROCOLITIS
Child: 1 mth-5 yr: 5mg/kg 4 times daily; 5-12 yr: 62.5 mg 4 times daily; 12-18 yr: 125 mg 4 times daily. Treat for 7-10 days.
 
Oral
STAPHYLOCOCCAL ENTEROCOLITIS
Adult: 0.5-2 g daily in 3-4 divided doses for 7 to 10 days. Use the lower dose unless ileus is impending or in severe infections.
 
Oral
ANTIBIOTIC-ASSOCIATED COLITIS DUE TO CL. DIFFICILE
Adult: 0.5-2 g daily in 3-4 divided doses for 7 to 10 days. Use the lower dose unless ileus is impending or in severe infections.
 
Oral
ANTIBIOTIC-ASSOCIATED COLITIS DUE TO CL. DIFFICILE
Child: 0.5-2 g daily in 3-4 divided doses for 7 to 10 days. Use the lower dose unless ileus is impending or in severe infections.
 
Intravenous
SERIOUS STAPHYLOCOCCAL OR OTHER GM+VE INFECTIONS
Adult: 0.5-2 g daily in 3-4 divided doses for 7 to 10 days. Use the lower dose unless ileus is impending or in severe infections.
 
Intravenous
STAPSERIOUS STAPHYLOCOCCAL OR OTHER GM+VE INFECTIONSHYLOCOCCAL ENTEROCOLITIS
Child: 0.5-2 g daily in 3-4 divided doses for 7 to 10 days. Use the lower dose unless ileus is impending or in severe infections.
 
Intravenous
OSTEOMYELITIS
Adult: 0.5-2 g daily in 3-4 divided doses for 7 to 10 days. Use the lower dose unless ileus is impending or in severe infections.
 
Intravenous
OSTEOMYELITIS
Child: 0.5-2 g daily in 3-4 divided doses for 7 to 10 days. Use the lower dose unless ileus is impending or in severe infections.
 
Intravenous
SOFT TISSUE INFECTIONS
Adult: 0.5-2 g daily in 3-4 divided doses for 7 to 10 days. Use the lower dose unless ileus is impending or in severe infections.
 
Intravenous
SOFT TISSUE INFECTIONS
Child: 0.5-2 g daily in 3-4 divided doses for 7 to 10 days. Use the lower dose unless ileus is impending or in severe infections.
 
Intravenous
SEPTICAEMIA
Adult: 0.5-2 g daily in 3-4 divided doses for 7 to 10 days. Use the lower dose unless ileus is impending or in severe infections.
 
Intravenous
SEPTICAEMIA
Child: 0.5-2 g daily in 3-4 divided doses for 7 to 10 days. Use the lower dose unless ileus is impending or in severe infections.
 
Intravenous
PROPHYLAXIS OF ENDOCARDITIS
Adult: 0.5-2 g daily in 3-4 divided doses for 7 to 10 days. Use the lower dose unless ileus is impending or in severe infections.
 
Intravenous
PROPHYLAXIS OF ENDOCARDITIS
Child: 0.5-2 g daily in 3-4 divided doses for 7 to 10 days. Use the lower dose unless ileus is impending or in severe infections.
   
Administration May be taken with or without food.
   
Precautions Renal impairment; neonates, elderly, pregnancy and lactation. Administer by slow IV only. Decrease thrombophlebitis by giving vancomycin slowly as a dilute solution (2.5-5 mg/ml) and rotate infusion sites frequently. Keep rate of infusion ≤10 mg/min. Serum trough vancomycin levels to be kept at 5-20 mcg/ml depending on severity of infections and sites of infection. Monitor renal function, blood counts and auditory functions regularly. Discontinue if tinnitus develops.
   
Potentially Life-threatening 
Adverse Drug Reactions
Ototoxicity, nephrotoxicity, eosinophilia, "red-man" syndrome (e.g. flushing, hypotension, erythema), urticaria, thrombophloebitis, hypersensitivity reactions.
   
Adverse Drug Reactions Stevens-Johnson syndrome; toxic epidermal necrolysis, blood dyscrasias such as neutropenia or thrombocytopenia.
   
Interactions Risk of increased nephrotoxicity with concomitant aminoglycosides, cisplatin, NSAIDs, amphotericin B, polymycin B, colistin or other nephrotoxic agents. Increased neuromuscular blockade with concomitant use of suxamethonium or vecuronium. Increased risk of ototoxicity with other aminoglycoside antibiotics, loop diuretics and ethacrynic acid. Increased risk of toxicity with methotrexate. Decreased vancomycin levels with dopamine, dobutamine. Increased risk of neutropenia with zidovudine.
   
   
 

 

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