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Indication & Dosage |
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| Intravenous |
| INITIAL CONTROL OF VARICEAL BLEEDING |
| Adult:
As argipressin: 20 units in 100 ml of glucose 5% infused over 15 min. |
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| Parenteral |
| TREATMENT OF CRANIAL DIABETES INSIPIDUS |
| Adult:
As argipressin: 5-20 units SC/IM every 4 hr. Doses range from 5-60 units daily. |
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| Precautions |
Heart failure; migraine; epilepsy; asthma or other conditions which might be exacerbated by fluid retention; renal impairment; hypertension or other conditions that may worse with BP increase. Adjust fluid intake to avoid fluid overload. Lactation, pregnancy (especially 3rd trimester as it may have oxytocic effect). |
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Potentially Life-threatening
Adverse Drug Reactions |
Pallor, vomiting, nausea, belching, abdominal cramps, tremor, pounding headache, vertigo, fluid retention, hyponatraemia, hypersensitivity reaction, sweating, urticaria, gangrene, desire to defecate, arrhythmias, bradycardia, angina, MI and bronchoconstriction. |
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| Adverse Drug Reactions |
Anaphylaxis; cardiac arrest or shock. |
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| Interactions |
Carbamazepine, chlorpropamide, clofibrate, urea, fludrocortisone and tricyclic antidepressants may potentiate the antidiuretic action of vasopressin. Demeclocycline, noradrenaline, lithium, heparin and alcohol may decrease antidiuretic action of vasopressin. Ganglionic blockers may increase sensitivity to the pressor effect of vasopressin. Increased risk of QT prolongation with dolasetron. |
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