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Indication & Dosage |
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Oral |
SHORT-TERM MANAGEMENT OF INSOMNIA |
Adult:
As conventional release tab: 10 mg immediately before bedtime; max: 10 mg/day. As controlled release tab: 12.5 mg immediately before bedtime. Elderly: As conventional tab: Initiate with a 5-mg dose before bedtime. As controlled release tab: 6.25 mg immediately before bedtime. |
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Administration |
May be taken with or without food. |
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Precautions |
Obstructive sleep apnoea, myasthenia gravis, compromised respiratory function, hepatic impairment. Caution in patients exhibiting symptoms of depression. Patients should be warned from doing any work involving mental alertness or motor coordination after ingestion of the drug. Pregnancy and lactation. Re-evaulate if insomnia fail to remit after 7-10 days. Max duration of treatment: 4 wk including tapering. |
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Potentially Life-threatening
Adverse Drug Reactions |
Amnesia, drowsiness, dizziness, diarrhoea, nausea, vomiting, abnormal thinking and behaviour, drugged feelings, back pain, ataxia, hiccups, confusion, euphoria, insomnia, vertigo, diplopia, abnormal vision. |
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Adverse Drug Reactions |
Hepatitis, anaphylactic reactions, "sleep-driving". |
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Interactions |
Increased sedation and incoordination with TCA. Increased sedation with haloperidol and alcohol. Small increase in zolpidem concentration with ketoconazole. Reduced effect of hypnotic effects with rifampicin. |
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