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Indication & Dosage |
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| Oral |
| HYPERTHYROIDISM |
| Adult:
Initially, 20-60 mg daily as a single or divided dose, reduced gradually once euthyroidism is achieved. Maintenance: 5-15 mg daily for at least 1 yr or 18 mth. |
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| Oral |
| HYPERTHYROIDISM |
| Child:
4-12 yr: Initially, 15 mg daily. |
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| Oral |
| GRAVE'S DISEASE |
| Adult:
Initially, 20-60 mg daily as a single or divided dose, reduced gradually once euthyroidism is achieved. Maintenance: 5-15 mg daily for at least 1 yr or 18 mth. |
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| Oral |
| GRAVE'S DISEASE |
| Child:
4-12 yr: Initially, 15 mg daily |
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| Oral |
| PREPARATION FOR THYROIDECTOMY |
| Adult:
Initially, 20-60 mg daily as a single or divided dose, reduced gradually once euthyroidism is achieved. Maintenance: 5-15 mg daily for at least 1 yr or 18 mth. |
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| Oral |
| PREPARATION FOR THYROIDECTOMY |
| Child:
4-12 yr: Initially, 15 mg daily. |
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| Oral |
| ADJUNCT TO RADIO-IODINE THERAPY |
| Adult:
Initially, 20-60 mg daily as a single or divided dose, reduced gradually once euthyroidism is achieved. Maintenance: 5-15 mg daily for at least 1 yr or 18 mth. |
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| Oral |
| ADJUNCT TO RADIO-IODINE THERAPY |
| Child:
4-12 yr: Initially, 15 mg daily |
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| Administration |
May be taken with or without food. (Take consistently w/ or without meals.) |
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| Precautions |
Liver diseases, pregnancy, lactation. |
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Potentially Life-threatening
Adverse Drug Reactions |
Mild leucopaenia, sore throat, mouth ulcers, fever, bruising, malaise; rarely cholestatic jaundice; nephrotic syndrome. Nausea, loss of taste, headache, arthralgia, alopoecia. |
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| Adverse Drug Reactions |
Agranulocytosis, aplastic anaemia, hypoprothrombinaemia, neutropaenia; hypothyroidism and goitre. |
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| Interactions |
Increased sensitivity to warfarin in hyperthyroidism and careful control required as patient is rendered euthyroid. |
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